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Bio-terrorism Early Warning Syndromic Surveillance

By Ronald A. Hellstern, M.D., FACEP
VP Medical Affairs - Emergisoft Corp.

The foundation of optimum bio-terrorism event management is early warning. A key epidemiological tenet is that the detection and reporting process must occur faster than the speed of the spread of the biological agent to make any difference in outcome. The emergency department (ED) is an ideal data source area upon which to focus this effort because it operates continuously around the clock and generally has more reporting capability than the typical physician’s office practice. Effective early warning in turn derives from the capabilities of local, state and federal systems of disease reporting. As medicine in general, and emergency medicine in particular, moves to integrate computers into what is now a paper-based world, the use of an electronic medical record (EMR) in the ED will make possible both real time disease symptom constellation (so called "syndromic") monitoring and the nearly instantaneous early identification of an unfolding bio-terrorism event.

Unfortunately, disease-reporting statutes are currently a hodge-podge of confusing and often conflicting local and state health department regulations. The timeliness of subsequent federal reporting varies widely from state to state. Until the period of the anthrax incidents following the September 11, 2001 World Trade Center/Pentagon terrorist attacks most communicable disease reporting relied on the completion and mailing of paper forms. Since the anthrax incidents some states have instituted 800 telephone numbers for the more immediate reporting of certain specific disease conditions, but few states currently support any form of electronic monitoring or reporting. Recognition and reporting timelines for biological events continues to be measured in days and weeks rather than in minutes and hours. Furthermore, until this surveillance can occur passively, without the need for data abstraction from one system and/or entry into yet another database or reporting system, public health data reporting compliance will remain as dismally inadequate as it is today.

The Congress and President Bush have recognized this need and a key provision of the recently enacted (summer 2002) Homeland Security Funding Bill contains a provision for up to $4.5B to assist the Centers for Disease Control (CDC) and State Health Departments in creating an ED-based syndromic surveillance system with local area wrap-up reporting occurring horizontally to State Health Departments and national reporting occurring vertically to the CDC.

Syndromic surveillance differs significantly from presenting complaint or final diagnosis surveillance and reporting. Monitoring patient presenting ED complaints for the purposes of bioterrorism early warning is problematic because these complaints are typically subjective and expressed in non-scientific terms. In addition, no standardized coding system exists for these so-called chief complaints. Final ED diagnosis is problematic because it is typically not coded at the time of the ED visit. In addition, since most EDs continue to operate in a paper-based environment the content of their medical records is neither searchable nor reportable, except on a manual basis and after the fact. Final diagnosis also varies depending upon individual provider interpretation of any given set of symptoms and signs.

The word "syndrome" implies within its medical meaning the lack of a discrete diagnosis. A medical syndrome is a collection of a group of symptoms and signs that are known to occur together in certain conditions but that do not necessarily add up to any single definable diagnosis. Most bioterrorism agents present with very non-specific symptoms or signs that are easily confused with common medical problems such as allergies, a cold or influenza. These common medical diagnoses (allergy, cold, the flu, etc.), if used as the basis of early warning surveillance, are prone to misinterpretation as insignificant findings.

The best possible early warning surveillance system should therefore focus on the earliest available patient data that is free from human interaction-induced variability. In this instance that is the specific patient symptoms and signs themselves, and not the presenting chief complaint or the final ED diagnosis. Thus syndromic surveillance is designed to look in real time for abnormal patterns of occurrence of groups of symptoms and signs, and to use these to alert the public health agencies long before any single individual could possibly identify an evolving event.

Of all the ED information systems solutions on the market, EmergisoftED is virtually the only one capable of supporting this real time syndromic surveillance effort without modification. In EmergisoftED, the Document Guide prompts the clinical data content and it can easily be quickly reconfigured to adapt to the specific event so we are sure to collect the appropriate bio-terrorism early warning data. Each clinical symptom or sign in the "syndrome" we are seeking for the purpose of early warning is collected and stored in the system as a discreet data point, making it both searchable and reportable in real time. EmergisoftED is the only EDIS currently possessing all of these essential characteristics.

For more information, contact Emergisoft Corporation, 800-682-7729, www.emergisoft.com.


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